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Invited Symposium: Progression of Non-Amnestic Dementias: Measurement and Intervention
Emily Rogalski
Neurodegenerative diseases can be classified by the molecular nature of the proteinopathy, the cellular aspects of the pathology, the anatomical distribution of the neurosynaptic loss, or the clinical features of the resultant phenotype. The relationship between structural neuroanatomy and clinical features is relatively consistent; however, the relationship of the clinical picture to the underlying disease process in neurodegenerative dementia is more complex. For example, the clinical syndrome primary progressive aphasia (PPA) can be caused by the neuropathology of either Alzheimer's disease (AD) or frontotemporal lobar degeneration (FTLD). This demonstrates that that there is no one to one relationship between clinical phenotype and underlying pathology. Disease progression in dementia syndromes is also variable and incompletely understood, with some patients declining more rapidly than others. This symposium will introduce approaches directed at establishing markers of etiology and progression of dementia syndromes. We will also highlight the potential use of these approaches in clinical trials and providing disease-staging expectations for patients and families.
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