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ANIMAL MODELS OF COGNITIVE AGING: PROMISE ON THE HORIZON

Mark B. Moss, Ph.D.
Professor and Chairman, Department of Anatomy and Neurobiology,
Boston University School of Medicine, Boston, MA, USA

Recent advances in transgenics, neuroimaging, neuroimaging, and behavioral assessment paradigms have provided new opportunities to develop more relevant animal models of normal human aging and age-related disease.  This course will provide a summary of the contribution of animal models toward our understanding of the neurobiological bases of cognitive change that occurs in normal human aging and age-related disease.   Studies from rodent to non-human primates will be reviewed.  Participants in this 1.5 hour course should be able to meet the following two objectives: (1) to gain an understanding of the types and range of animal models that  are being used to provide insight to our understanding of cognitive changes associated with normal aging, mild cognitive impairment and Alzheimer’s disease and (2) to learn the type, mechanism, and efficacy of interventions being used to test new approaches to slow, arrest, or even reverse the effects of cognitive aging in health and disease.