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Presenter: Kerry Scott Lane, MD

Acetaminophen toxicity in the liver is well established. One of the known toxic effects of this commonly used drug is depletion of the most important antioxidant, glutathione. Disease states linked to depletion of glutathione and excessive amounts of oxidized glutathione, versus reduced glutathione, include Diabetes, Atherosclerosis, AIDS, Alzheimer’s, Pregnancy Induced Hypertension (PIH), Toxemia of Pregnancy and others. Regressive Autism is a condition that has defied a definitive pathobiology to date. The attachments enclosed reveal that acetaminophen, by exacerbating an already depleted glutathione antioxidant system due to a preexisting condition, triggers autism in the peri-vaccination period by reducing glutathione levels to below a critical level. Adequate glutathione levels are crucial to the effective functioning of the Metallothionein (MT) System. The MT system is involved in metabolism of metals, as is glutathione. However, the MT system is especially critical to the metabolism of Zinc in the brain. In states of depleted glutathione and excess oxidized glutathione, free Zinc is released in the mitochondria of brain cells. This free zinc is toxic to the mitochondria, causing cellular hypoxia and a generalized neurological malfunctioning that we now recognize as Autism.