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Presenter: Gerard Mullin, MD
Format: MP4 Video file of Slides and Audio
The program will first present a focused review of the role of the gut microbiota in health and disease then discuss a series of key experiments that cement the relationship of the gut microbiome to obesity and its metabolic complications (i.e., diabetes, non-alcoholic fatty liver disease). Specifically, compelling data from the human microbiome project in humans along with manipulation of the gut microbiome via fecal transplantation, antibiotics in tandem with diet will be featured. Finally, the mechanisms of how gut flora regulate weight balance via metabolism, satiety-appetite, genes, inflammation, endocrine, insulin resistance, intestinal permeability etc. will be outlined. In the second segment of the program, we will define prebiotics and review its application in health and disease. The program will present the role of diet in modulating the gut microbiome along with data illustrating the inverse relationship of dietary fiber intake to obesity risk and the associated shifts in the human microbiome. The therapeutic manipulation of the gut microbiome and its ability to alter metabolism and produce weight loss will be presented. The anti-obesity effects of prebiotics and probiotics in experimental models and in human clinical studies will be reviewed. Summary points will include recommendations for future studies.
Learning Objectives:
- Know the role of the gut microbiota in human health and disease.
- Become familiar with the pathophysiology of obesity and how alterations in the gut microflora lead to obesity.
- Understand how prebiotics and probiotics can promote a lean metabolism by fostering a healthy gut microbiome.
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