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Stress contributes to the pathogenesis of cardiovascular disease from increasing sympathetic tone to enhancing cholesterol deposition, increasing lipid oxidation, and augmenting platelet aggregation. In order to turn off the mental fire driving cardiovascular disease, one must use all available tools including heart rate variability biofeedback, cognitive behavioral techniques, biochemical individuality, and genetic testing. From the working of a person's neurotransmitter system to the perceptual frameworks that may reveal an underlying deficiency or inefficiency, from group dynamics to history of trauma, the diagnosis of cardiovascular disease is an end point of a long life process