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Current research indicates that development and maintenance of IBD requires the combined additive effects of at least three components: genes regulating intestinal barrier function and repair, altered intestinal microflora, and impairment of innate immunity leading to excesses of adaptive immunity. This model implies that diverse mechanisms underlie IBD in different patients and that each patient may have a distinctive illness with unique therapeutic requirements. This session will review the substantial database of human clinical trial data utilizing diet, nutritional supplements, botanicals, probiotics, prebiotics and mind-body therapies for treatment of patients with IBD and provide a structured framework for individualizing therapeutic choices.