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Pain is one of the most common reasons patients seek our help. Nutrition is often considered when counseling our patients, and it takes a high level of conviction to motivate people to change. Patients with chronic fatigue, fibromyalgia, and a myriad of pain conditions are much more dramatically affected by nutrition than most of us appreciate. A successful plan can be explained as a matter of three rules that need to be followed. Nutritional supplementation can also be helpful, and various nutrients will be discussed that can help improve healing.